Fibrofolliculomas (also called trichodiscomas) are small (2–4 mm), white-to-flesh coloured, smooth, dome-shaped bumps. Acrochordons or skin tags are small, soft 1–2 mm bumps that look like a wart with a thin neck. Birt–Hogg–Dubé syndrome (BHD), also Hornstein–Birt–Hogg–Dubé syndrome, Hornstein–Knickenberg syndrome, and fibrofolliculomas with trichodiscomas and acrochordons[1] is a human, adult onset, autosomal dominant genetic disorder caused by a mutation in the folliculin (FLCN) gene.
Fibrofolliculomas are most commonly associated with Birt-Hogg-Dubé syndrome, a genetic disorder linked to mutations in the FLCN gene. This syndrome is characterized by the presence of multiple fibrofolliculomas, trichodiscomas, acrochordons and an increased risk of renal cell carcinoma. We report successful treatment of fibrofolliculomas in a patient with BHDS using a combination of fractionated and nonfractionated ablative CO 2 10,600 nm laser (CO2RE, Candela) resulting in improvement of the lesion count, lesion size, and overall textural appearance. A rare, benign (not cancer) tumor that forms in a hair follicle (the opening on the skin through which hair grows).
fibrofolliculomas, Fibrofolliculomas appear as small, raised, whitish bumps that usually occur on the face, ears, neck, and chest. They tend to grow slowly but can increase in size and number over time. Fibrofolliculomas are abnormal growths of the hair follicles with epithelial strands extending into the surrounding stroma. Generally, they are lighter than skin color, but can be skin-colored or slightly erythematous, and are dome shaped. Fibrofolliculomas and trichodiscomas in BHD typically develop in the third to fourth decades of life.
