Ocular signs are present in at least 2/3 of the patients affected by hereditary ochronosis. [16–20] In our review scleral hyperpigmentations were the most common finding (Figure 2, left). Slightly ...
Ochronosis is a rare disorder which manifests as a bluish-black discoloration of the skin and mucosa. It is categorized into endogenous or exogenous forms. This form is also referred to as ... Hydroquinone has long been used as the gold standard treatment for hyperpigmentation, yet despite its effectiveness, it has been associated with a severe adverse reaction known as exogenous ochronosis ...
ochronosis, Exogenous ochronosis is a potential side effect of prolonged use of hydroquinone, particularly at higher concentrations or with long-term use. It is characterized by blue-black pigmentation and can develop even after stopping the treatment. However, diagnosing the exact cause of your symptoms requires careful consideration of several factors. Please do meet a dermatologist who specialises in pigmentation, as ochronosis can take quite some time to manage, if at all. I have been using Picoway (I am the India KOL for the device) for managing ochronosis in skin types V/VI, with some early good results - however, this is not a regular indication, and I would recommend that you follow up with an expert in the field.
ochronosis, Ochronosis is associated with prolonged use of hydroquinone (generally greater than 3 months). Unfortunately, once you get, it can be quite difficult to treat especially with darker skin types (Fitzpatrick 4-6). Hydroquinone is a bleaching agent that specifically inhibits the enzyme homogentisic acid oxidase, which can in cetain patients result in the accumulation of this substance on the collagen fibers in tissues where it is applied. This reaction over long term use can result in grey brown and bluish black patches and bumps over the cheeks and forehead called exogenous ochronosis. The majority of ... Long-term use of hydroquinone can lead to a condition called ochronosis, which causes the skin to become dark and thick.
There are also concerns about the safety of long-term systemic use of glutathione for skin lightening. Since Cosmelan contains hydroquinone at a higher percentage , using it for a prolonged time or using it repeatedly can lead to a condition called ochronosis. If Cosmelan is used as suggested by the manufacturer it should decrease hyperpigmentation and not increase it, and is completely safe.
